Total Protein

Also Know as: Protein, Serum Protein Test

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Last Updated 1 November 2024

What is the Total Protein test?

In medical terms, total protein is a measure of all the proteins in your blood. Proteins are important building blocks in the body and play a vital role in cell growth, repair, and maintenance. The test to measure protein levels in your blood is often part of a comprehensive metabolic panel, which may be done as part of a routine health exam.

  • Types of Proteins: There are two types of proteins commonly measured via total protein tests: albumin and globulin. Albumin, the smallest protein, is responsible for transporting various substances through your blood. Globulin is a larger protein that encompasses a variety of different proteins, including enzymes, antibodies, transport proteins, and clotting factors.

  • Purpose of Total Protein Test: A total protein test is often conducted to assess the function of your liver and kidneys or to diagnose certain conditions like liver disorder, kidney disease or nutritional problems.

  • Procedure of the Test: The test usually involves a simple blood draw. The healthcare provider will clean a small area of your arm with an antiseptic wipe, then insert a small needle into a vein for collecting a blood sample.

  • Results Interpretation: Normal total protein levels vary, but generally fall between 6 and 8.3 grams per deciliter (g/dL). High or low protein levels could indicate a health problem and warrant further testing.


When is Total Protein test Required?

Total protein is a vital test that is typically part of a comprehensive metabolic panel. Many circumstances may necessitate the need for a Total Protein Test, and the primary reasons include:

  • Health Evaluation: As part of a routine health evaluation, total protein tests may be conducted. These tests are part of a comprehensive metabolic panel that provides an overview of a person's overall health status.

  • Symptom analysis: If a person is experiencing symptoms like fatigue, unexplained weight loss, or swelling in the ankles, feet, or legs, a total protein test may be required to help diagnose the cause of these symptoms.

  • Disease Monitoring: Individuals with certain conditions such as liver disease or kidney disorder may require regular total protein tests. This is to monitor the progression of the disease and the effectiveness of the treatment.

  • Nutritional Assessment: Total protein tests can be useful in assessing a person's nutritional status. It can indicate malnutrition or other nutritional imbalances.


Who Requires Total Protein test?

The Total Protein Test is not only for those in the medical field. Various groups of people may require a Total Protein Test, and these include:

  • Patients with liver or kidney conditions: These individuals may need a total protein test to monitor their condition and assess the effectiveness of their treatment.

  • Individuals exhibiting symptoms of malnutrition: Total protein tests can help determine if a person is getting enough essential nutrients in their diet.

  • People with certain autoimmune diseases: Conditions like lupus or rheumatoid arthritis can affect protein levels. Regular testing can help manage these conditions.

  • Individuals undergoing physical recovery: After a major surgery or traumatic injury, total protein levels can provide insight into a person's healing process.


What is Measured in Total Protein test? 

Total protein measurement evaluates the total amount of two classes of proteins found in the blood: albumin and globulin. Both play essential roles in the body’s function, and these roles include:

  • Albumin: This is the most abundantly present protein in the blood plasma, making up about 60% of total blood proteins. It functions primarily to regulate blood volume by controlling the amount of water in the bloodstream.

  • Globulins: Making up the remaining 40% of proteins in the blood, globulins play various roles, including transporting lipids and fat-soluble vitamins, and forming antibodies in the immune response.


What is the methodology of Total Protein test?

  • The methodology of Total Protein involves a series of biochemical methods to determine the total protein concentration. This method is based on the logic that proteins can bind to certain dyes, resulting in a color change, from which the protein concentration can be indirectly measured.

  • The most common methodology is the Biuret method, which involves the use of copper ions that bind to the peptide bonds in proteins.

  • Another widely used methodology is the Lowry method, which is a bit more sensitive and precise, but also more time-consuming and susceptible to interference from other substances.


How to prepare for Total Protein?

  • The preparation for the Total Protein test is fairly simple and straightforward.

  • It usually involves fasting for a certain period before the test, as food can affect the protein levels in the blood.

  • It's also recommended to avoid vigorous physical activity before the test. This is because it can temporarily increase protein levels.

  • It's important to inform your doctor of any medicines/supplements you're taking, as some of them can affect protein levels.

  • Hydration is also important, as dehydration can falsely elevate protein levels.


What happens during Total Protein?

  • During a Total Protein test, a lab technician will collect a blood sample from a vein in your arm using a small needle.

  • The needle prick may cause a brief sting or pinch, but it's generally not painful.

  • The blood sample is sent to a lab, where it's analyzed for total protein, as well as albumin and globulin, the two main types of proteins in the blood.

  • The results are usually available within a few days and will be interpreted by your healthcare provider in the context of your overall health and specific medical condition.


What is Total Protein test Normal Range?

Total protein test measures the amount of two major groups of proteins in the body. These are albumin and globulin. Proteins are vital parts of all cells and tissues. The normal range for total protein is 6 to 8.3 grams per deciliter (g/dL).


What are Reasons for Abnormal Total Protein test results?

  • Dehydration can cause your total protein level to be high.

  • Chronic inflammation or infections like viral hepatitis or HIV can raise your total protein level.

  • Some types of cancer, particularly multiple myeloma, can cause high protein levels.

  • Malnutrition or nutritional deficiencies can cause your total protein level to be low.

  • Conditions that affect the kidneys, such as nephrotic syndrome, can cause your total protein level to be low.

  • Liver diseases such as cirrhosis can cause your total protein level to be low.


How to Maintain a Normal Total Protein Range

  • Eat a balanced diet with sufficient protein. Foods rich in protein include meat, poultry, fish, dairy products, legumes, and nuts.

  • Stay hydrated. Dehydration can lead to increased total protein levels.

  • Maintain a healthy weight. Obesity can affect protein metabolism and lead to abnormal total protein levels.

  • Manage chronic conditions. If you have a chronic condition like diabetes, HIV, or kidney disease, regular monitoring and treatment can help maintain a normal total protein level.

  • Avoid excessive alcohol consumption. Alcohol can damage the liver and affect protein production.


Precautions and Aftercare Tips Post Total Protein Test

  • After the blood sample is taken, keep the bandage on the injection site for a few hours to prevent bleeding.

  • If you feel dizzy or faint after the blood draw, sit or lie down until you feel better.

  • Drink plenty of water to help your body recover and replace the volume of blood drawn.

  • If the puncture site becomes red, swollen, or painful, contact your healthcare provider. These could be signs of an infection.

  • Wait for your results patiently. Your doctor will explain the results and any necessary next steps once they are available.


Why Book with Bajaj Finserv Health?

There are several reasons why you should consider booking with Bajaj Finserv Health, including:

  • Precision: Bajaj Finserv Health's affiliated labs utilize cutting-edge technology to ensure the utmost accuracy in test results.

  • Cost-effectiveness: Our individual diagnostic tests and service providers are comprehensive without putting a strain on your pocket.

  • Home sample collection: We offer the convenience of having your samples collected from your home at a time that suits you.

  • Nationwide coverage: No matter where you are in India, our medical test services are accessible.

  • Convenient payment options: You can choose to pay through one of our available payment options, either cash or digital.


Note:

This is not medical advice, and this content should only be considered for informational purposes only. Consult with your healthcare provider for individual medical guidance.